Published December 1987
by Brill Academic Publishers .
Written in English
|The Physical Object|
|Number of Pages||320|
Studies of tumor viruses revealed that specific genes (called oncogenes) are capable of inducing cell transformation, thereby providing the first insights into the molecular basis of cancer. However, the majority (approximately 80%) of human cancers are not induced by viruses and apparently arise from other causes, such as radiation and chemical carcinogens. Oncogene and Cancer. This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and kauainenehcp.com by: 7. Apr 01, · Geoffrey M. Cooper is a retired cancer researcher, professor, and scientific administrator, having held positions at Harvard Medical School and Boston University. He is the author of the cell biology text, The Cell, as well as several books on cancer. The Prize, his first novel, has won National Indie Excellence and Readers' Favorite Book Awards.4/5. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung kauainenehcp.com: Pinar Erkekoglu.
It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer. A cancer cell may contain one or more oncogenes, which means that one or more components in this pathway will be abnormal. Tumor Suppressor Genes A second group of genes implicated in cancer are the "tumor suppressor genes.". Tumor suppressor genes are normal genes whose ABSENCE can lead to cancer. The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a. Proto-oncogenes are genes that normally help cells grow. When a proto-oncogene mutates (changes) or there are too many copies of it, it becomes a "bad" gene that can become permanently turned on or activated when it is not supposed to be. When this happens, the cell grows out of control, which can lead to cancer. This bad gene is called an oncogene.
Oncogenes were first discovered on cancer-causing viruses, but they also are found in all normal cells. The original, unmutated wild-type allele of an oncogene is known, strictly, as the proto-oncogene. The wild-type proto-oncogene promotes cell growth and division. During development of a multicellular organism, cell division is closely controlled. Proto-oncogenes. The genes that code for the positive cell-cycle regulators are called proto-oncogenes. Proto-oncogenes are normal genes that, when mutated in certain ways, become oncogenes —genes that cause a cell to become cancerous. Consider what might happen to the cell cycle in a cell with a recently acquired oncogene. The second edition of this authoritative text details major advances and developments in the field, such as the identification of many new tumor suppressor genes and the striking progress in understanding signal transduction pathways leading to cell proliferation. Oncogenes, Second Edition, addresses the needs of advanced undergraduates, graduate students, medical students, physicians, and 5/5(1). The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, .